港口城市江州,南城分局刑侦队女副队长王若楠和卧底警员邱天联手破案,却发现了隐藏在案件背后的江州黑势力大哥刘东涉嫌贩毒的案情。为侦破此案,已可归队的邱天孤身继续卧底,决意捣毁刘东集团。此行动务必极度保密,王若楠成为了邱天的唯一联络人。邱天卧底刘东组织,经历怀疑,靠着英勇机智,获得了刘东的信任,成为组织内的重要人员。邱天受命保护被刘东威胁的、知晓自己警察身份的前女友李菲菲和她的现任丈夫、药品企业家周志国。邱天得到参加交易毒品的机会,但警方连续两次抓捕行动,都被内外因素破坏,邱天也几乎暴露。此时刘东背后的秘密供货人却浮出水面。邱天为查找毒源,违背王若楠的指令,带刘东潜逃。邱天赌博式的举动,却得到惊人的真相:原来周志国才是真正的幕后黑手。面对这起勾结境外,制毒、贩毒的重大毒品犯罪,最终,邱天和王若楠一起将罪恶之源斩断于江州。
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