京城突现夺心狂魔,频频作案杀人而后夺走心脏,杨宇轩奉命捉拿凶手,期间为保护朱一品不幸葬身火海。朱一品悲痛万分,发誓要为杨宇轩报仇。皇帝突发恶疾,面向全社会寻找神医,朱一品怀疑夺心狂魔就隐藏在宫闱之中,毅然揭下皇榜入宫。经过一番艰苦调查,朱一品发现太医郑载农就是夺心狂魔,可惜最终被他趁乱逃跑。朱一品在寻找郑载农的过程中发现了宁亲王意图谋反的狼子野心,为此他与医馆同僚们几次三番被卷入凶恶险境,但都凭借默契的合作和日益进步的推理能力一次次成功破案,同时也将宁亲王的阴谋一点点揭露。最终,他们深入敌穴,再一次成功阻止了宁亲王的谋反行动,守护住了国家的太平。
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