45岁的中学老师张幸福（许晴饰）有一个幸福的家庭：丈夫马三强（林永健饰）是电视台知名主持人；儿子（朱元冰饰）不仅考上重点大学最好的专业，更是麻省理工的交换生。然而这外人眼中的美满在张幸福45岁生日这天被打破：她遇到了二十多年前的初恋男友严俊（温升豪饰），但身为医生的他带来的却是噩耗——她得了乳腺癌，仅有3%的存活希望。当她试图把病情告诉家人时，却遭遇丈夫下岗、母亲老年痴呆症发作、儿子逃学，不靠铺的弟弟（薛之谦饰）和小姑子（王晓晨饰）也来凑热闹，家中一派乌烟瘴气。张幸福决定不告诉家人病情，发誓要在人生的最后阶段做回真正的自己……她以最靓丽的形象示人，并悄悄为自己所爱的家人们安排好所有的生活。在这不能说的秘密中，她经历了丈夫和闺蜜的双双“背叛”、初恋男友的百般呵护、儿子的叛逆、弟弟的误解、小姑子的抱怨。但她始终坚信“身体的癌症可以治疗，家庭的癌症更可以治愈”。因此，她以宽容之心面对名人老公马三强的“出轨”，以纯净之心面对初恋情人严俊的回归。她努力释放最完美的自己，并最终赢得了所有人的理解与爱。
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